Muller’s ratchet states that in asexual populations, deleterious mutations accumulate in that population irreversibly (like a ratchet). 1 Since populations in early evolutionary life would have been asexual, Muller’s ratchet presents a very serious problem to evolution.
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Sanford, J. C., & Baumgardner, J. (2008). Genetic Entropy & the Mystery of the Genome (3rd ed.). Waterloo, NY: FMS Publications.
- Sanford, 2008, p. 137 ↩